It is used to treat people with open-angle glaucoma and intraocular hypertension (increased pressure in the eye). Latanoprost lowered my pressure but caused severe heart palpitations, increased blood pressure and anxiety. BRAND NAME(S): Xalatan. Purpose: To study any interaction between pilocarpine and latanoprost when administered together, and to determine the optimal timing of dosage to maximize reduction of intraocular pressure (IOP). No pharmacokinetic interactions between latanoprost and timolol were observed although there was an approximate 2-fold increased concentration of the acid of latanoprost in aqueous humour 1-4 hours after administration of latanoprost/timolol compared to monotherapy. Call your doctor if you notice these changes. ... Drug Interactions . Drug Interactions . There are no available data regarding ophthalmic use in pregnant women. Drug Interactions: In vitro . When latanoprost and timolol (a different drug that also is used to treat glaucoma) are used in combination, there is a greater reduction in pressure than when either drug is used alone. DRUG INTERACTIONS Drug-Drug Interactions In vitro studies have shown that precipitation occurs when eye drops containing thimerosal are mixed with latanoprost. These conditions may eventually affect your eyesight. It is similar to a natural chemical in the body (prostaglandin) and works by regulating the flow of fluid within the eye which results in lower pressure. Methods: Nineteen adult patients with either primary open-angle glaucoma or ocular hypertension participated in a single-center, prospective case study with masked observer. Latanoprost is a prescription drug. Latanoprost/Timolol. Find everything you need to know about Latanoprost Ophthalmic (Xalatan), including what it is used for, warnings, reviews, side effects, and interactions. If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart. Distribution: Volume of distribution: 0.16 L/kg. Animal studies. the drug. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with latanoprost that may apply to you. As a healthcare professional of medicine, you are expected to have an intimate knowledge of many of the key drug interactions and the consequences those interactions have. It comes as an ophthalmic solution (eye drop). Common side effects of Xalatan include. It has a role as an antiglaucoma drug, an antihypertensive agent, an EC 4.2.1.1 (carbonic anhydrase) inhibitor and a prodrug. Latanoprost eye drops is used to treat certain kinds of glaucoma. Pregnancy. ABOUT THIS MEDICATION What the medication is used for: Sandoz Latanoprost is used to treat ocular hypertension (high pressure in the eye) in patients with open-angle glaucoma or ocular hypertension. Give as directed by your veterinarian. Sandoz Latanoprost: Latanoprost belongs to a class of medications called prostaglandin analogs. Timolol belongs to a class of medications called beta-adrenergic receptor blockers (also known as "beta-blockers"). Interactions. At no time is this more true than when treating glaucoma. Interactions are similar to other prostaglandin analogs. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for LATANOPROST. Pregnancy. No adequate and well-controlled studies have been conducted to evaluate the use of latanoprost during human pregnancy. Drug interactions-If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart ... -Hypersensitivity to latanoprost or any other ingredient-Gradual and permanent change of iris color to brown may occur after several months or years. Used in the treatment of open-angle glaucoma and ocular hypertension. ... drug interactions, allergic reactions, or … Reproduction studies of latanoprost showed embryofetal lethality in rabbits; no embryofetal lethality was observed at a dose ~15 times higher than the recommended human ophthalmic dose (RHOD); in 4 of 16 pregnant rabbits, no viable fetuses were present at a dose ~80 times RHOD Proton-pump inhibitors. Macular edema, including cystoid macular edema, reported; Caution caution with aphakic and pseudophakic patients with a torn posterior lens capsule, or in patients with known risk factors for macular edema Pharmacokinetics: Absorption: Absorbed through the cornea.Time to peak plasma concentration: 2 hr. Side effects include a burning or stinging sensation, mild eye redness, growth of eyelashes, or color change of the iris or around the eye. Drug excretion in breast milk is unknown. 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